538 Skin commensals promote optimal sebaceous gland function by engaging in an immune-sebum circuit

Sebum provides vital cutaneous functions including moisture retention and defense against the external environment, pathogens. Despite well-defined homeostatic of sebum in fortifying skin barrier, role microbiota-immune system axis regulation remains unclear. We have recently shown that keratinocyte-derived cytokine thymic stromal lymphopoietin (TSLP) promotes secretion through T cell stimulation. TSLP cell-deficient mice display reduced secretion, suggesting an immunologic release. hypothesized commensals could represent a trigger for recruitment release, thereby controlling secretion. To test this hypothesis, we measured germ-free (GF) found 50% reduction release compared to conventionally-raised specific-pathogen-free (SPF) controls (p = 0.004). Moreover, GF exhibited expression number. Restoring mice, via delivery adeno-associated viral vector, did induce sebaceous glands (SGs). this, however, SG activity was not restored. determine if function be defective adoptively transferred SPF mouse-derived cells into RAG KO mice. However, still restore even with overexpression. Thus, addition number skin, harbor SGs are responsive TSLP-stimulated cells. Ongoing studies investigating mechanism by which microbiome alters responsiveness By studying immune-sebum circuit, novel therapeutic targets sebum-dysregulation diseases may identified utilized improve patient health quality life.